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Assignment 4

Due: 11pm EST, 4/18/2025

3. Clinical QA

In this section, you will use Generative AI tools to answer the following medical questions from the MedM- CQA dataset:

Question 1: In a female, intraocular metastasis most commonly occurs from which of the following gynae- cological primary?

A)  Breast

B)  Ovary

C)  Cervix

D)  Endometrium

Question 2: A research was undertaken by a group of psychiatrists and obstetricians to assess postpartum depression in mothers giving birth to male versus female children according to the Edinburgh depression scale (EPDS). What test should be used to compare the outcomes?

A)  Student’s t-test”

B)  Paired t-test

C)  Chi-square test

D)  Pearson’s correlation coefficient

Question 3: A 27-year-old woman comes to the office for counseling prior to conception.  She states that a friend recently delivered a newborn with a neural tube defect and she wants to decrease her risk for having a child with this condition.  She has no history of major medical illness and takes no medications. Physical examination shows no abnormalities. It is most appropriate to recommend that this patient begin supplementation with a vitamin that is a cofactor in which of the following processes?

A)  Biosynthesis of nucleotides

B)  Protein gamma glutamate carboxylation

C)  Scavenging of free radicals

D)  Transketolation

E)  Triglyceride lipolysis

(a) Use a Generative AI tool of your choice to answer the medical questions provided above. Prompt the AI tool multiple times, using each of the following prompt engineering strategies:

• Zero-shot

• One-shot

• Chain-of-thought

Record each of your prompts, as well as the corresponding AI response, in the table below:

(b) Which of your three prompts produced the best result? Explain your reasoning.